Water permeation through stratum corneum lipid bilayers from atomistic simulations
نویسندگان
چکیده
منابع مشابه
In vitro permeation of nickel salts through human stratum corneum.
Allergic contact dermatitis due to nickel salts is common. It is therefore important to measure the permeation of these salts through the stratum corneum (SC), the primary rate-limiting domain in skin. An advanced diffusion system and analytical techniques now enable better measurement of the flux than was possible in earlier experiments. Human SC was prepared by trypsinization of dermatomed ca...
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Computer simulation has become an important tool for the study of biomolecular systems. This thesis deals with molecular dynamics simulations of one-component lipid bilayers, which may serve as models for biological membranes. The main scientific contributions are: • It is possible to analyze the electrostatic contribution to the surface tension at a lipid-water interface in terms of dipole-dip...
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We present atomistic molecular dynamics results for fully hydrated bilayers composed of ceramide NS-24:0, free fatty acid 24:0 and cholesterol, to address the effect of the different components in the stratum corneum (the outermost layer of skin) lipid matrix on its structural properties. Bilayers containing ceramide molecules show higher in-plane density and hence lower rate of passive transpo...
متن کاملThe physics of stratum corneum lipid membranes.
The stratum corneum (SC), the outermost layer of skin, comprises rigid corneocytes (keratin-filled dead cells) in a specialized lipid matrix. The continuous lipid matrix provides the main barrier against uncontrolled water loss and invasion of external pathogens. Unlike all other biological lipid membranes (such as intracellular organelles and plasma membranes), molecules in the SC lipid matrix...
متن کاملSkin diseases associated with the depletion of stratum corneum lipids and stratum corneum lipid substitution therapy.
The skin is the largest organ of the body, whose main function is to protect the body against the loss of physiologically important components as well as harmful environmental insults. From the inside to the outside, the skin comprises three major structural layers: the hypodermis, the dermis and the epidermis. The epidermis contains four different sublayers, the stratum corneum (SC), stratum g...
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ژورنال
عنوان ژورنال: Soft Matter
سال: 2009
ISSN: 1744-683X,1744-6848
DOI: 10.1039/b911257j